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E-cigarette, as a first nicotine product, was declared by 16% of exclusive e-cigarette users and 20.7% of dual users ( p = 0.6)

Methylglyoxal also forms AGEs through reactions with proteins that are associated with cellular dysfunction, age-related pathologies, and neurodegenerative diseases (Ramasamy et al., 2006

Here's how: The smoke from a cigarette contains over 4,000 chemicals, including tar, carbon monoxide, and nicotine

Because they do not burn tobacco, these products do not contain carbon monoxide, producing a nicotine-containing aerosol, a natural tobacco taste fundamentally different from cigarette smoke